Minneapolis–Saint Paul is a metropolitan area in the Upper Midwestern United States centered around the confluence of the Mississippi, Minnesota, and St. Croix rivers in the U.S. state of Minnesota. It is commonly known as the Twin Cities after the area's two largest cities, Minneapolis and Saint Paul. Minnesotans often refer to the two toget…Minneapolis–Saint Paul is a metropolitan area in the Upper Midwestern United States centered around the confluence of the Mississippi, Minnesota, and St. Croix rivers in the U.S. state of Minnesota. It is commonly known as the Twin Cities after the area's two largest cities, Minneapolis and Saint Paul. Minnesotans often refer to the two together simply as "The Cities". The area is Minnesota's economic, cultural, and political center.