Fort Myers is a city in and the county seat of Lee County, Florida, United States. As of the 2020 census, the population was 86,395; it was esti…Fort Myers is a city in and the county seat of Lee County, Florida, United States. As of the 2020 census, the population was 86,395; it was estimated to have grown to 95,949 in 2022, making it the 25th-most populous city in Florida. Together with the larger and more residential city of Cape Coral, it anchors the Cape Coral–Fort Myers metropolitan statistical area, which encompasses Lee County and has a population of 834,573 as of 2023.