At Wimbledon in 2017, Medvedev was fined after emptying his wallet and throwing coins at umpire Mariana Alves following a five-set loss to Belgium's Ruben Bemelmans. He disputed a series of controversial calls and said after the match "it was very hot out there" and couldn't remember if he'd asked for Alves' removal.

A photographer walking on the court at match point sparked a decision that infuriated Daniil Medvedev and caused a six-minute delay.

Daniil Medvedev's greatest victory came at the USTA Billie Jean King National Tennis Center in New York when he won the 2021 U.S. Open, the only major title of his career.