If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.

Tight end George Kittle and cornerback Charvarius Ward were surprise no-shows at Thursday’s practice, sidelined by leg injuries that suddenly put their availability in question for the 49ers’ game Sunday at the Los Angeles Rams.

George Kittle missed practice on Thursday because of a hamstring injury. Here's the latest on the TE's status for the Week 3 49ers vs. Rams game.