Injuries have accumulated quickly for the 49ers. In addition to Bosa and Purdy, star tight end George Kittle (hamstring), wide receiver Jauan Jennings (shoulder, ankle) and left guard Ben Bartch (ankle) have been hampered by injuries.

The San Francisco 49ers were dealt a disappointing update on a potential Trey Hendrickson trade. He's been linked to them for weeks.

The San Francisco 49ers could use some defensive reinforcements given the injuries they are dealing with this season, and they are reportedly interested in a handful of New York Jets players ahead of the Nov.

San Francisco star defensive end Nick Bosa tore the ACL in his right knee and will miss the rest of the season.

With Nick Bosa out for the season, the most important thing for the San Francisco 49ers is clearly the progression of rookie Mykel Williams. Williams recorded his first sack of the season, and it does appear that he has progressed this season. Notably, the team is working to get him into pass-rush situations where he can win.

After suffering a serious injury in Week 3, San Francisco star Nick Bosa will be on the sidelines for the foreseeable future.

The 49ers’ remaining schedule would be challenging even with Fred Warner and Nick Bosa. Without them? Good luck.

Bijan Robinson must dominate a weakened 49ers defense missing Fred Warner and Nick Bosa for Atlanta Falcons to win in Week 7.