For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

The 49ers will play the Raiders on Saturday, August 16, at 4 p.m. ET. The San Francisco 49ers vs. Las Vegas Raiders game will air on the NFL Network and locally on FOX5 in Las Vegas. The game will be available to stream for out-of-market viewers on NFL+.

The San Francisco 49ers will face the Las Vegas Raiders in week 2 of the NFL preseason on Saturday at Allegiant Stadium.