Tottenham Hotspur host Chelsea in the Premier League on Saturday.Spurs won 3-0 at Everton in their last league fixture, but were defeated by Newcastle United in the League Cup on Wednesday.Chelsea

Tottenham Hotspur host Chelsea in the Premier League on Saturday evening at the Tottenham Hotspur Stadium, in what is the start of what could prove a difficult run, with Manchester United and Arsenal up next.

Kickoff from Tottenham Hotspur Stadium is set for 1:30 p.m. ET. Tottenham are +170 money line underdogs in the latest DraftKings Sportsbook odds while Chelsea are +150 money line favorites. A draw comes in at +260 and the total sits at 2.

The 2–2 draw with Qarabag leaves the Blues with plenty of work to do if they’re to claim a place in the round of 16 without having to navigate an extra round. Despite the midweek disappointment, Enzo Maresca defended his wholesale rotation amid criticism from Wayne Rooney.

Preview the matchup between Chelsea FC and Tottenham Hotspur with predictions, odds, over/under, betting lines and more.

Manchester United are winless in their last seven meetings against Spurs in all competitions. No side has lost more home Premier League matches in 2025 than Tottenham Hotspur's nine. Manchester United are unbeaten in their last four Premier League games, their joint best-run of form under Amorim.

Chelsea return to Stamford Bridge to host Wolves as they look to claim consecutive victories in the Premier League.

Preview the matchup between Manchester United and Tottenham Hotspur with predictions, odds, over/under, betting lines and more.

Newcastle United legend, Alan Shearer, has given his predictions for some of the key games in the Premier League this weekend. These will be the last set