Business Wire

Megakaryon Corporation Initiates First-in-Human Clinical Trial of Allogenic Human iPSC-Derived HLA Homozygous Platelets (MEG-002)

KYOTO, Japan--(BUSINESS WIRE)--Megakaryon Corporation (hereinafter, Megakaryon) today announces its clinical trial of allogenic human iPSC-derived HLA homozygous platelets (Development Code: MEG-002) ...
Medscape

Trends in HLA Antibody Screening and Identification and Their Role in Transplantation

Determining the specificity of HLA antibodies is arguably one of the most important contributions by the HLA laboratory today. For patients that have low-to-moderate levels of antibody, using a ...
Fred Hutch

HLA haplotype allelic variations can influence leukemia recurrence after blood stem cell transplantation

“Since the discovery of transplantation as a life-saving therapy for blood malignancies by Dr. E Donnall Thomas, there have been major advances that have significantly lowered the side effects and ...
The New England Journal of Medicine

Antigen Presentation by B Cells in Multiple Sclerosis

Both genetic factors and environmental influences, including infection with Epstein–Barr virus, contribute to multiple sclerosis susceptibility. The association between susceptibility to multiple ...
ascopubs.org

Assessment of Functional Status of Human Leukocyte Antigen Class I Genes in Cancer Tissues in the Context of Personalized Neoantigen Peptide Vaccine Immunotherapy

Somatic mutations in HLA genes were detected in the tumor data of five patients, and somatic HLA gene loss of heterozygosity was identified in the tumor data of five patients. Complete or partial ...