Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

This year’s Lasker Basic Medical Research Award recognizes the contributions of Drs. Richard Hynes, Erkki Ruoslahti, and Timothy Springer for their discovery and characterization of integrins, a major ...

Chugai Pharmaceutical has reported a new humanized antibody (Ab, SOF-10) that targets latent TGF-β1 and selectively blocks protease- and integrin αVβ8-mediated latent TGF-β1 activation.

The movement of leukocytes from the circulatory system to the site of inflammation and subsequent attachment forms an integral part of the innate immune system. The three steps of leukocyte rolling, ...