A new study identifies MARK3 as a kinase that promotes type I interferon production by phosphorylating GEF-H1 and activating the TBK1–IRF3 antiviral signaling pathway.

A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...

Tyrosine kinase signalling underpins the cellular response to a myriad of cytokines that regulate immunity, haematopoiesis and tissue homeostasis. Engagement of a cytokine with its cognate receptor ...

Protein kinases are a large family of enzymes that catalyse the transfer of phosphate groups from ATP to specific amino acid residues on target proteins, thereby modulating their activity, ...

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns. Scientists at St. Jude Children's ...

Comprehensive reagent portfolio enables end-to-end mechanistic investigation of the highly conserved Hippo signaling ...

Within contemporary peptide science, increasing attention has shifted toward molecules with the potential of influencing ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

The growing scientific interest in short regulatory peptides has brought increasing attention to fragments that, despite ...

Explore how oncogenes and signaling pathways converge and diverge in cancer, shaping diagnostic and therapeutic strategies for personalized interventions. This convergence is accompanied by ...

Somatic alterations in the phosphoinositide 3-kinase (PI3K) pathway are frequent oncogenic drivers in cancer and are particularly relevant in estrogen receptor–positive breast cancer, where PI3K ...