The data shows that immune cells converge at sites of motor neuron loss and TDP-43 pathology with distinct patterns depending on the ALS type.

Patients with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, live an average of only three years after ...

Developing motor neurons from stem cells taken directly from amyotrophic lateral sclerosis (ALS) patients offers new hope for better understanding and treatment of the fatal neurodegenerative disorder ...

Scientists could be on the verge of a medical breakthrough in understanding what is driving cases of amyotrophic lateral sclerosis (ALS)—the most common form of motor neurone disease. The exact cause ...

ALS, also known as Lou Gehrig's disease, is among the most challenging neurological disorders: relentlessly progressive, universally fatal, and without a cure even after more than a century and a half ...

A cellular recycling system called CMA was found to be impaired in ALS motor neurons. Reduced CMA activity was linked to TDP-43 protein clumps, a hallmark of most ALS cases. Boosting CMA may be a ...

University of Wollongong (UOW) scientists have developed a breakthrough therapy that clears toxic proteins from nerve cells—a discovery that advances the work of the late Professor Justin Yerbury and ...

A new medicine, discovered by scientists, protects nerve cells damaged by motor neurone disease (MND), offering hope of substantially slowing the progression of "one of the cruellest diseases".

Click to share on Facebook (Opens in new window) Facebook Click to share on X (Opens in new window) X Patrick was diagnosed with motor neurone disease (MND) in February 2023 after experiencing balance ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these proteins is relatively simple. Neurons in the brain, however, face a ...