Kickoff from Bank of America Stadium is set for 1 p.m. ET, and the Bills are 7.5-point favorites, according to the latest Bills vs. Panthers odds. The over/under for total points scored is 46.5. Before you make any Panthers vs. Bills picks, make sure to check out what the SportsLine Projection Model has to say.

James Cook rolled his way to a career performance while guiding the Buffalo Bills to a rebound victory over the Carolina Panthers in Week 8. In doing so, he set

As if losing 40-9 to the Bills wasn't bad enough, the Panthers must now deal with a devastating season-ending injury.

The Panthers and quarterback Andy Dalton, who started Sunday for an injured Bryce Young, were held to three points until the fourth quarter, when Chuba Hubbard scored on a 3-yard rush with some of Buffalo’s starters sitting on the bench.

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With starting quarterback Bryce Young sidelined by an ankle injury, Carolina lost its first game this season at Bank of America Stadium. Next up: Green Bay Packers at Lambeau Field.

Regardless of Bryce Young's injury status, Andy Dalton will start as QB for the Carolina Panthers on Sunday versus the Buffalo Bills.

Panthers QB Andy Dalton made an ugly mistake at the end of the first half against the Bills. Fans let him hear about it on social media.