Nature

OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin pathway suppression

The five-year survival rate for non-small-cell lung cancer (NSCLC) remains poor, primarily due to tumor invasion and metastasis. This study evaluates the anti-metastatic potential of the oncolytic ...
ascopubs.org

Safety and tolerability of intratumorally administered OH2, an oncolytic herpes simplex virus 2, in patients with advanced solid tumors: A phase I dose escalation clinical study.

Multi-antigen active specific immunotherapy induced long-term remission and prevent colorectal cancer relapse. This is an ASCO Meeting Abstract from the 2020 ASCO Annual Meeting I. This abstract does ...
ascopubs.org

The phase 1 clinical trial of anti–PD-1 ab plus intrahepatic injection of oncolytic virus (OH2) combined radiotherapy of liver metastasis in stage IV melanoma.

Efficacy and safety of transcatheter arterial infusion of immune checkpoint inhibitors in locoregional unresectable or in-transit acral melanoma: A multi-center real-world study. This is an ASCO ...
Nature

A Multi-Omics Dataset of Prostate Cancer Response to Oncolytic Virus OH2 Treatment

Prostate cancer is the most common malignant tumor of the male genitourinary system, especially metastatic castration resistant prostate cancer (mCRPC), which currently lacks effective treatment ...