Following the publication of AlphaFold2 and RoseTTAFold in 2021, the field of protein structure prediction has moved quickly to incorporate these advances into protein engineering. The applications of ...

Protein design aims to create customized antibodies for therapies, biosensors for diagnostics, or enzymes for chemical reactions. An international research team has now developed a method for ...

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent ...

Researchers from the University of Science and Technology of China (USTC), led by Prof. Liu Qi, in collaboration with Harvard Medical School's Marinka Zitnik lab, have developed a novel deep ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

How the proteins in our bodies bind together to form protein complexes plays a critical role in numerous cell ...

A multicolored 3D model of an enzyme binding double-stranded DNA against a light purple background Computational enzyme design could allow for reactions not seen in nature. Credit: Ian Haydon ...

Researchers recently published findings that could lay the groundwork for applying quantum computing methods to protein structure prediction. Researchers from Cleveland Clinic and IBM recently ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...

AI2 Incubator’s Jenny Cronin (left), interviews David Baker, director of the University of Washington’s Institute for Protein Design. (GeekWire Photo / Charlotte Schubert) The Institute for Protein ...

By tracking aromatic ring movements inside proteins, researchers uncovered details of the molecular flexibility that enables ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...