Bitter taste receptors are not only expressed in oral cavity cells but also in the gastrointestinal lining. To understand the diverse functions of these receptors, understanding the structure is ...

With MassiveFold, scientists have unlocked AlphaFold's full potential, making high-confidence protein predictions faster and more accessible, fueling breakthroughs in biology and drug discovery. Brief ...

For more than a decade, artificial intelligence has been touted as a way to dramatically accelerate drug discovery. Yet ...

In living organisms, proteins perform key functions required for life activities by interacting to form complexes. Determining the protein complex structure is crucial for understanding and mastering ...

Receptor proteins, expressed on the cell surface or within the cell, bind to different signaling molecules, known as ligands, initiating cellular responses. Taste receptors, expressed in oral tissues, ...

At a virtual conference in November 2020, the winner of a biennial protein-structure-prediction challenge was announced: AlphaFold. Created by Google DeepMind, this computational tool had blown its ...

In 2020, news headlines repeated John Moult’s words at the end of a stunning competition: Artificial intelligence had “solved” a long-standing grand challenge in biology, protein structure prediction.

Proteins are the molecular workhorses of cells. To understand their functions, scientists soon realized that they had to figure out proteins’ shapes. But solving a protein structure is a challenging ...