New modeling shows how synonymous mutations -- those that change the DNA sequence of a gene but not the sequence of the encoded protein -- can still impact protein production and function. New ...

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20100 ...

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20^100 possible variants-more combinations than atoms in the observable universe.

Genetic diseases that result from truncated proteins can be targeted by so-called nonsense suppression therapies—drugs that prevent protein translation from terminating prematurely. A new ...

Tsukuba, Japan—Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

Increased plaque forming capability of N protein mutant viruses carrying either S202R or R203M mutations A recent paper by Syed et al. demonstrates that mutations in the Nucleocapsid (N) protein, one ...

Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing. Studying the role of ...