Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other side with Rams desperate for a win.

Former 49ers players Richard Sherman and Donte Whitner ripped San Francisco's defense for allowing Justin Jefferson's 97-yard touchdown.

When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan would likely keep him out two weeks.