In addition to QB C.J. Stroud and K Ka'imi Fairbairn, Houston will be without OLs Tytus Howard and Ed Ingram and d DB Jalen Pitre.

When Jacksonville visits Houston on Sunday, the Jaguars will get a boost with new receiver Jakobi Meyers while the Texans will be missing their top offensive

The Houston Texans have back their top two wide receivers following Sunday's win over the San Francisco 49ers.

Although no touchdowns were scored, the Texans offense started off well against the Denver Broncos, and it looked like Stroud was about to have a very impressive day, until he suffered a concussion on a late-slide attempt that will now keep him out this weekend against the Jaguars.

An AFC South matchup is coming to NRG Stadium this weekend. The Jacksonville Jaguars will visit the Houston Texans as 1.5-point favorites on Sunday. The Indiana

Here's who the experts have winning on Sunday afternoon at NRG Stadium between the Jacksonville Jaguars and Houston Texans.

They also won’t have right tackle Tytus Howard (concussion), right guard Ed Ingram (knee), defensive back Jalen Pitre (concussion), fullback Jakob Johnson (hamstring) or linebacker Christian Harris (shin). Houston has ruled out all six of them.

Preview the Week 10 matchup between the Jacksonville Jaguars and Houston Texans with predictions, odds, over/under, spread, betting lines and more.

Here’s how the Texans and Jaguars stack up statistically ahead of Sunday's matchup at NRG Stadium in Week 10 of the NFL regular season.

Houston Texans running back Nick Chubb (21) rushes for yards during the fourth quarter of an NFL football matchup at EverBank Stadium, Sunday, Sept. 21, 2025, in Jacksonville, Fla. The Jaguars defeated the Texans 17-10. / Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images