Researchers at Spain’s CNIO have mapped 20,000 distinct DNA repair “scars,” building the first human REPAIRome. This atlas ...

Type 2 diabetes is characterised by chronic hyperglycaemia, which disrupts the balance between reactive oxygen species production and endogenous antioxidant defences. This oxidative stress leads to ...

A research team has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular degeneration and that targeting specific retinal cell types may lead to treatments ...

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell ...

REPAIRome specifically addresses the repair of one of the most serious types of DNA damage, DNA double-strand breaks (DSBs).

KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic ...

Irvine, Calif., Dec. 3, 2024 – A research team co-led by the University of California, Irvine has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A study reveals the secrets behind the rodent’s remarkable ability to live 10 times longer than expected, without cancer or ...