Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according ...

KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic ...

A research team has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular degeneration and that targeting specific retinal cell types may lead to treatments ...

Researchers at Spain’s CNIO have mapped 20,000 distinct DNA repair “scars,” building the first human REPAIRome. This atlas ...

Type 2 diabetes is characterised by chronic hyperglycaemia, which disrupts the balance between reactive oxygen species production and endogenous antioxidant defences. This oxidative stress leads to ...

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

REPAIRome specifically addresses the repair of one of the most serious types of DNA damage, DNA double-strand breaks (DSBs).

Irvine, Calif., Dec. 3, 2024 – A research team co-led by the University of California, Irvine has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

The three types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Here's how to identify their ...

A study reveals the secrets behind the rodent’s remarkable ability to live 10 times longer than expected, without cancer or ...