Nick Pivetta allowed a leadoff homer by Jung Hoo Lee and then settled down to tie his season high with 10 strikeouts in six innings and lead the San Diego Padres to a 5-1 victory against the San Francisco Giants on Tuesday night.

The San Francisco Giants lost 5-1 to the San Diego Padres on Tuesday at Petco Park after a first-inning home run from Jung Hoo Lee.

It probably happened again for thousands of fans in San Diego's Petco Park on Monday night. Padres shortstop Xander Bogaerts sent a deep fly to left field that ended up in the seats and was initially ruled a home run. It appeared to have slipped out of Giants left fielder Heliot Ramos ' glove and into the seats.

SAN DIEGO — Roughly a week ago, Kai-Wei Teng and Nick Pivetta faced off at Oracle Park in what ended up being a 10-run loss for the Giants. There would be no blowout on Tuesday night at Petco Park, but the result was the same.

Padres manager Mike Shildt expressed his frustration with the review process on the controversial play in San Diego's loss to the San Francisco Giants.

Ramos led off the ballgame by sending an 88 mph fastball from the Padres’ Nestor Cortes into the left-field bleachers, giving the Giants an early 1-0 lead. Rafael Devers followed up with a solo homer of his own, making him and Ramos the first Giants to go back-to-back to begin a road game since Chuck Hiller and Duke Snider in 1964.

Heliot Ramos, Rafael Devers and Wilmer Flores homered off Nestor Cortes in the first inning and the San Francisco Giants beat San Diego 4-3 to hand the Padres their fourth straight loss.

Video replay controversy costs the Padres in a 4-3 loss to the Giants, as Xander Bogaerts' home run was overturned for fan interference despite the video showing otherwise.