They calculated data using the formula [Theoretical AUC = theoretical dose / actual CL]. The theoretical dose was based on the various weight descriptors (ideal weight [IDW], ABW, lean body mass, and ...

This study, too, was limited to the pharmacoeconomic impact of a weight-based protocol and did not examine the effectiveness of using a dosing-weight formula.

Oxaliplatin-based adjuvant chemotherapy is used for stage III colon cancer, but may induce disabling neurotoxicity. We previously showed that the incidence of oxaliplatin-induced peripheral ...