Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The molecular mechanisms controlling the ...

In bacteria, septum formation frequently initiates before the last steps of chromosome segregation. This is notably the case when chromosome dimers are formed by homologous recombination. Chromosome ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Auxin dictates root architecture via the Auxin ...

Apoptosis and inflammation generally exert opposite effects on tumorigenesis: apoptosis serves as a barrier to tumour initiation, whereas inflammation promotes tumorigenesis. Although both events are ...

Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing ...

Here, using X‐ray crystallography and structure‐guided mutagenesis, we provide the first molecular insights into the structure of OGT, how it binds UDP‐GlcNAc and aligns it for inverting O‐GlcNAc ...

This month's cover highlights the article Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation by A.-D. Brunner, M. Mann and colleagues. A new ultra-high ...

Cover: Pseudostratified tracheal epithelium from newborn mice depicting cell boundaries (E‐cadherin, blue) and multiple motile cilia (acetylated α‐tubulin, red) protruding from multiple basal bodies ...

Precursor protein targeting toward organellar surfaces is assisted by different cytosolic chaperones. We demonstrate that the chloroplast protein translocon subunit Toc64 is the docking site for Hsp90 ...

Impact Our results provide a therapeutic paradigm for MYC‐overexpressing B‐cell lymphomas, exploiting their vulnerability to oxidative stress. Given the synergistic action of IACS‐010759 and high‐dose ...

Histone deacetylases (HDACs)—an enzyme family that deacetylates histones and non‐histone proteins—are implicated in human diseases such as cancer, and the first‐generation of HDAC inhibitors are now ...

The formation of cell type‐specific complexes is crucial for the development of complex organisms. Unique combinations of LIM‐homeodomain (LIM‐HD) proteins are thought to form a transcriptional ‘LIM ...