The EMBO Journal2h
Gene therapy for epilepsy targeting neuropeptide Y and its Y2 receptor to dentate gyrus granule cells
Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...
The EMBO Journal19h
Structural basis for the type I-F Cas8-HNH system
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The Cas3 nuclease is utilized by canonical ...
The EMBO Journal3d
HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43
HIV-1 Vpu triggers the cleavage of TDP-43 by stimulating Caspase 3 activation. The cleavage products generated can induce the ...
The EMBO Journal3d
Next generation of “magic bullets”, solutions from the microbial pangenome
These toxins provide new tools for precision cancer medicine, bringing us closer to the elusive “magic bullet.” In addition, ...
The EMBO Journal3d
Histamine synthesis and transport are coupled in axon terminals via a dual quality control system
Neurotransmitters are key for synaptic transmission at axon terminals, but their transport modalities remain debated. This ...
The EMBO Journal5d
An hepatitis B and D virus infection model using human pluripotent stem cell-derived hepatocytes
This study presents human pluripotent stem cell-derived hepatocyte-like cells (HLCs) as a culture system that expands the ...
The EMBO Journal19h
Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glycolysis impairment in the fat body of ...
The EMBO Journal12d
The gray boundaries of aberrant shortening of the cellular timekeepers’ edges
This vesicular traffic of Telomeric DNA complexes, together with telomerase, helps T cells to handle telomere attrition and ...
The EMBO Journal11d
Human genomic DNA is widely interspersed with i-motif structures
(iMs) are knot-like DNA structures structures formed in the nuclei of human cells and believed to provide critical genomic regulation. This study uses immunoprecipitation and next-generation ...
The EMBO Journal3d
Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal5d
Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced clustering
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal3d
Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Plants evolve nucleotide-binding leucine-rich ...