The D38A variant was the most frequent followed by the M13dup variant. Researchers identified 2 unique variants in the transthyretin (TTR) gene that are predominant among Korean patients with ...

The improvements occurred without any safety concerns, and the trial further indicated that higher total doses enable longer dosing intervals. Umedaptanib pegol, a novel anti-fibroblast growth factor ...

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired autoimmune neurological disorder in which both T-cell-mediated and humoral immune mechanisms target healthy myelinated ...

The novel anti-IL-36 receptor monoclonal antibody recibokibart demonstrated favorable safety and efficacy in treating patients with acute generalized pustular psoriasis (GPP) in a phase 1b study ...

My recent liver biopsy was a case study of Murphy’s Law in action. And as I share the details of my saga, I’m mindful that my experience is the exception, not the rule. I do not want to discourage ...

Iptacopan has a relatively positive efficacy and safety profile when used to treat PNH. A study found iptacopan to be a promising therapy in the management of paroxysmal nocturnal hemoglobinuria (PNH) ...

In diagnosed cases of cutaneous mastocytosis, investigations to rule out systemic mastocytosis may be appropriate. A young child with a small chest lump and anemia was found to have cutaneous ...

Statistical analysis revealed that severe cytopenia and splenomegaly were significant prognostic factors for survival. Cytopenia and splenomegaly appear to be the main drivers for poor prognosis in ...

Belinda Moser of ExamOne takes a blood sample from Marie Bedirlian, whose 14-year-old son, Brayden, has Duchenne. Bedirlian is a DMD carrier. (Photo by Larry Luxner) Pradeep Mammen, MD, an expert on ...

The prevalence of AATD in the offspring of parents with AATD in our study was 37%. A risk of pregnancy complications and adverse birth outcomes has been observed in mothers with alpha-1 antitrypsin ...

Immunohistochemistry analyses detected a correlation between increased CDK1 expression and higher levels of LDH, a key indicator of greater disease severity in DLBCL. Higher levels of CDK1 expression ...

Further research is needed to establish if there is a causative link between avacopan and liver injury. A patient with microscopic polyangiitis (MPA)—a form of antineutrophil cytoplasmic antibody ...