The D38A variant was the most frequent followed by the M13dup variant. Researchers identified 2 unique variants in the transthyretin (TTR) gene that are predominant among Korean patients with ...

The improvements occurred without any safety concerns, and the trial further indicated that higher total doses enable longer dosing intervals. Umedaptanib pegol, a novel anti-fibroblast growth factor ...

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired autoimmune neurological disorder in which both T-cell-mediated and humoral immune mechanisms target healthy myelinated ...

My recent liver biopsy was a case study of Murphy’s Law in action. And as I share the details of my saga, I’m mindful that my experience is the exception, not the rule. I do not want to discourage ...

In diagnosed cases of cutaneous mastocytosis, investigations to rule out systemic mastocytosis may be appropriate. A young child with a small chest lump and anemia was found to have cutaneous ...

The novel anti-IL-36 receptor monoclonal antibody recibokibart demonstrated favorable safety and efficacy in treating patients with acute generalized pustular psoriasis (GPP) in a phase 1b study ...

The prevalence of AATD in the offspring of parents with AATD in our study was 37%. A risk of pregnancy complications and adverse birth outcomes has been observed in mothers with alpha-1 antitrypsin ...

Immunohistochemistry analyses detected a correlation between increased CDK1 expression and higher levels of LDH, a key indicator of greater disease severity in DLBCL. Higher levels of CDK1 expression ...

Hemolysis ceased completely in 2 patients after receiving 20 mg of rituximab. Low-dose rituximab may offer transient efficacy in patients with autoimmune hemolytic anemia (AIHA), including those with ...

Further research is needed to establish if there is a causative link between avacopan and liver injury. A patient with microscopic polyangiitis (MPA)—a form of antineutrophil cytoplasmic antibody ...

91.7% of prognostic studies reported a significant association between bilirubin levels and outcomes. The levels of bilirubin and alkaline phosphatase, as well as composites including these 2, can be ...

Iptacopan has a relatively positive efficacy and safety profile when used to treat PNH. A study found iptacopan to be a promising therapy in the management of paroxysmal nocturnal hemoglobinuria (PNH) ...