The San Francisco 49ers are looking to win consecutive games for the first time since September when they host the Carolina Panthers on Monday Night Football.

The San Francisco 49ers have a big matchup against the Carolina Panthers that will swing the playoff odds in a big way. If the 49ers want to walk out of Week 12 with an 8-4 record and an easy walk into the playoffs, they need a few key names to become big-time players .

Justine Lindsay, the NFL’s first transgender cheerleader who performed on the Carolina Panthers’ squad, dished about the reason for departing the organization. Lindsay claimed it had something to do with being transgender. Lindsay departed the team in August after being on the Carolina TopCats since 2022.

The 49ers welcome the Panthers for a Week 12 prime-time clash between two teams working to secure a playoff spot.

Writing at ESPN, Aaron Schatz sees the Panthers needing more help at wide receiver and in the middle of their offensive line.

The 49ers (7-4) are seeking a second straight win Monday night when they host the upstart Carolina Panthers (6-5).

The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.

Carolina and quarterback Bryce Young hope to thrust themselves into national spotlight against 49ers on Monday Night Football.

The Carolina Panthers have already exceeded their win total from a season ago. The franchise appears to be on the right track thanks to a strong 2025 offseason.