Then, on Thursday, there was Isaac Guerendo. With 1:39 left in the 49ers' game against the Seattle Seahawks and clinging for ...

Isaac Guerendo had a 76-yard run in the fourth quarter to help the San Francisco 49ers defeat the Seattle Seahawks, 36-24.

Guerendo had a chance to score a touchdown on Thursday, but chose to slide down short in order to preserve a 49ers win ...

Isaac Guerendo purposely bailed on what would have been a game-sealing touchdown against the Seahawks on "Thursday Night ...

In his best game of the season -- last week versus the Arizona Cardinals -- Isaac Guerendo finished with 2.2 fantasy points.

The 49ers running back room is depleted after Jordan Mason suffered a shoulder injury on "Thursday Night Football." ...

The fourth-round pick in the 2024 NFL draft took 10 carries for 99 yards in the 49ers’ 29-24 win over the Seattle Seahawks.

Guerendo rushed 10 times for 99 yards in the 49ers ' 36-24 win over the Seahawks on Thursday night.

San Francisco 49ers rookie running back Isaac Guerendo saves his career-long rush for the perfect time as he races 76 yards ...

Rookie running back Isaac Guerendo speaks to reporters about his huge game after the San Francisco 49ers' 36-24 win over the ...

The San Francisco 49ers have avoided the worst-case scenario with running back Jordan Mason. 49ers head coach Kyle Shanahan told reporters Friday that ...

San Francisco 49ers running back Jordan Mason is scheduled for tests to determine the severity of a shoulder injury that ...