Then, on Thursday, there was Isaac Guerendo. With 1:39 left in the 49ers' game against the Seattle Seahawks and clinging for ...

Isaac Guerendo had a 76-yard run in the fourth quarter to help the San Francisco 49ers defeat the Seattle Seahawks, 36-24.

Guerendo had a chance to score a touchdown on Thursday, but chose to slide down short in order to preserve a 49ers win ...

Isaac Guerendo purposely bailed on what would have been a game-sealing touchdown against the Seahawks on "Thursday Night ...

The 49ers running back room is depleted after Jordan Mason suffered a shoulder injury on "Thursday Night Football." ...

Guerendo's big play has created quite the debate in the 49ers locker room. The rookie running back claims he was told to ...

San Francisco 49ers rookie running back Isaac Guerendo saves his career-long rush for the perfect time as he races 76 yards ...

Jordan Mason was off to a strong start on Thursday night, but he wasn't around for the end of the team's win. Mason injured ...

San Francisco 49ers running back Jordan Mason is scheduled for tests to determine the severity of a shoulder injury that ...

San Francisco's Isaac Guerendo seals the 49ers' win with a 76-yard run in the final two minutes, then Kyle Juszczyk scores to ...

Shanahan’s defense had its busiest game of the season — 78 snaps versus 65 for the offense. Still, the 49ers won the ...

Rookies excelled but so did the trusted connection between Brock Purdy and George Kittle, not to mention Deebo Samuel and the ...