Then, on Thursday, there was Isaac Guerendo. With 1:39 left in the 49ers' game against the Seattle Seahawks and clinging for ...

Isaac Guerendo had a 76-yard run in the fourth quarter to help the San Francisco 49ers defeat the Seattle Seahawks, 36-24.

Guerendo had a chance to score a touchdown on Thursday, but chose to slide down short in order to preserve a 49ers win ...

Isaac Guerendo purposely bailed on what would have been a game-sealing touchdown against the Seahawks on "Thursday Night ...

The 49ers running back room is depleted after Jordan Mason suffered a shoulder injury on "Thursday Night Football." ...

In his best game of the season -- last week versus the Arizona Cardinals -- Isaac Guerendo finished with 2.2 fantasy points.

In his best game of the season, Isaac Guerendo finished with 1.9 fantasy points -- 5 carries, 19 yards. That was in Week 3 ...

Guerendo rushed 10 times for 99 yards in the 49ers ' 36-24 win over the Seahawks on Thursday night.

San Francisco 49ers rookie running back Isaac Guerendo saves his career-long rush for the perfect time as he races 76 yards ...

Jordan Mason was off to a strong start on Thursday night, but he wasn't around for the end of the team's win. Mason injured ...

San Francisco 49ers running back Jordan Mason is scheduled for tests to determine the severity of a shoulder injury that ...

San Francisco's Isaac Guerendo seals the 49ers' win with a 76-yard run in the final two minutes, then Kyle Juszczyk scores to ...