Then, on Thursday, there was Isaac Guerendo. With 1:39 left in the 49ers' game against the Seattle Seahawks and clinging for ...

Isaac Guerendo had a 76-yard run in the fourth quarter to help the San Francisco 49ers defeat the Seattle Seahawks, 36-24.

Guerendo had a chance to score a touchdown on Thursday, but chose to slide down short in order to preserve a 49ers win ...

Isaac Guerendo purposely bailed on what would have been a game-sealing touchdown against the Seahawks on "Thursday Night ...

The 49ers running back room is depleted after Jordan Mason suffered a shoulder injury on "Thursday Night Football." ...

In his best game of the season -- last week versus the Arizona Cardinals -- Isaac Guerendo finished with 2.2 fantasy points.

In his best game of the season, Isaac Guerendo finished with 1.9 fantasy points -- 5 carries, 19 yards. That was in Week 3 ...

Deebo Samuel shared a playful response to Isaac Guerendo after the 49ers rookie running back didn't score his first NFL ...

Guerendo rushed 10 times for 99 yards in the 49ers ' 36-24 win over the Seahawks on Thursday night.

The 49ers rookie class delivered under the light, with Malik Mustapha and Isaac Guerendo also making significant ...

San Francisco 49ers rookie running back Isaac Guerendo saves his career-long rush for the perfect time as he races 76 yards ...

San Francisco 49ers running back Jordan Mason is scheduled for tests to determine the severity of a shoulder injury that ...