The Indianapolis Colts and Jacksonville Jaguars go to battle in an AFC South duel in Week 5 with the Jaguars desperately seeking their first win of the season.

The San Francisco 49ers are gearing up to host the Arizona Cardinals at Levi's Stadium in Santa Clara, California, on Sunday, ...

Can the Jacksonville Jaguars find a win this Sunday vs. the Indianapolis Colts on Sunday? We discuss that and more in today's ...

The Jaguars might be even more desperate given how their season is unfolding. They know only one NFL team — the 1992 San ...

Our first touchdown scorer picks for Week 5 expect Travis Etienne to put the Jags on his back and find the end zone early.

Here are the final injury designations for the Week 5 matchup between the Indianapolis Colts and Jacksonville Jaguars.

Indianapolis Colts quarterback Anthony Richardson is trending to become a gametime decision for the team's Sunday matchup against the Jaguars.

Here is a closer look at three critical matchups to watch in the Indianapolis Colts Week 5 matchup vs. the Jaguars.

SportsLine AI reveals the top Week 5 NFL prop picks for sites like PrizePicks, Underdog Fantasy, and Sleeper Fantasy ...

The Jacksonville Jaguars (0-4) will battle through attrition against the Colts (2-2) Sunday in their 'Prowler Throwbacks'. A ...

Jacksonville remains the only winless NFL team, but the Colts haven't beaten the Jaguars on the road since 2014.

When defenses prepare for Buffalo’s offense, they have to start with Josh Allen, one of the league’s elite quarterbacks and a ...