Journal of Neurology, Neurosurgery and Psychiatry (JNNP)

Current Issue

Short report: Cluster analysis showed long-term cognition can be predicted by looking at regional grey matter atrophy in the ...
BMJ

Neurological immune-related adverse events with checkpoint inhibitor therapy: challenges for the neurologist

Immune checkpoint inhibitors (ICI) have had a dramatic effect on cancer outcomes with their use increasing as indications expand. Despite impressive efficacy across a range of tumour types, their role ...
BMJ

Impact of early intervention on outcome following mild head injury in adults

Background: The impact of mild head injury is variable and determinants of outcome remain poorly understood. Results of previous intervention studies have been mixed. Objectives: To evaluate the ...
BMJ

Imaging of vertebral artery stenosis: a systematic review

Professor Hugh Markus, Centre for Neuroscience, St George’s University of London, Cranmer Terrace, London SW17 0RE, UK; hmarkus{at}sgul.ac.uk Background and purpose: Posterior circulation stroke ...
BMJ

Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome (central pontine and/or extrapontine myelinolysis) in 25 patients

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India Correspondence to Dr Ashalatha Radhakrishnan, Department of Neurology, Sree Chitra Tirunal Institute for ...
BMJ

Spasms of amputation stumps.

Two patients are presented with muscle spasms in an amputation stump. Neither patient experienced neuropathic pain nor phantom sensations, though phantom sensory phenomena, severe pain, and lack of ...
BMJ

Fixed and dilated pupils after trauma, stroke, and previous intracranial surgery: management and outcome

OBJECTIVES To clarify whether different causative events (trauma, stroke, intracranial surgery), time of intervention, and treatment mode influence outcome, patients with fixed and dilated pupils ...
BMJ

Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer’s disease

Background and aim: Inflammation has been extensively implicated in the pathogenesis of Alzheimer’s disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, ...
BMJ

Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease

4 MRC Cognition and Brain Sciences Unit and University of Cambridge Neurology Unit, Addenbrooke’s Hospital, Cambridge, UK Correspondence to: Professor J R Hodges, MRC Cognition and Brain Sciences Unit ...
BMJ

Idiopathic intracranial hypertension: 12 cases treated by venous sinus stenting

Background: The high pressures documented in the intracranial venous sinuses in idiopathic intracranial hypertension (IIH) could be the result of focal stenotic lesions in the lateral sinuses ...
BMJ

Amitriptyline enhances the central component of physiological tremor

OBJECTIVES Postural tremor is a regularly encountered side effect of amitriptyline which can be strong enough to cause discontinuation of therapy. The aim was to characterise amitriptyline induced ...
BMJ

The effects of temperature on human compound action potentials.

The upper limbs of 10 healthy subjects were cooled and then warmed over physiological temperature ranges. The compound action potentials of median digital nerves, median sensory nerve at the wrist, ...