Nov 14, 2025 · Background Megakaryocytes are traditionally recognized as cells responsible for platelet production. However, beyond their role in thrombopoiesis, megakaryocytes also participate in …

Mar 7, 2005 · Dilutional coagulopathy is a common complication in severely injured patients and a consequence of blood loss, administration of synthetic colloids and red blood cell concentrates to …

Mar 19, 2013 · Correction of coagulopathy before central venous catheter (CVC) insertion is a common practice; however, when ultrasound guidance is used this is controversial as mechanical …

To the Editor, We read with interest the paper “Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses” [1]. We appreciate our …

Mar 2, 2001 · Coagulopathy is frequently seen in ICU patients. These patients may increase ICU costs considerable by their higher need of blood products. Detailed information about incidence and …

Background Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic …

Apr 5, 2011 · Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care. We carried out a multicentre study of coagulopathy in …

Mar 13, 2009 · Dilutional coagulopathy was induced by phased blood withdraw, salvaged erythrocyte retransfusion and volume substitution with hydroxyethyl starch. After the dilutional procedure the …

Mar 13, 2008 · The dilutional coagulopathy led to a decrease in circulating coagulation factors, a prolonged PT and a decreased TG. The substitution with PCC and pFFP normalized the impaired …

Oct 8, 2007 · Introduction The purpose of this study was to assess the safety of percutaneous dilational tracheostomy (PDT) performed by experienced operators in critically ill patients with liver disease …