Sep 9, 2005 · Troponin consists of three subunits: an inhibitory subunit (TnI), a Ca 2+ -binding subunit (TnC), and a tropomyosin-binding subunit (TnT). Ca 2+ -binding to TnC is believed to …

Dec 12, 2007 · There is ample evidence that Ca 2+ concentration and dynamics, intrinsic cross-bridge properties, and even troponin C (TnC) Ca 2+ binding and dissociation can all modulate …

Each heartbeat is triggered by a pulse of intracellular calcium ions which bind to troponin on the actin-containing thin filaments of heart muscle cells, initiating a change in filament structure …

The findings demonstrate the interrelationships among troponin's detailed dynamics, troponin's regulatory actions, and the pathogenesis of cardiomyopathy linked to troponin mutations.

Jan 1, 2015 · Binding of Ca 2+ induces conformational changes within and distal to the complex. This causes the protein tropomyosin to move along actin and reveal specific binding sites for …

Jun 6, 2017 · We show that two of these tropomyosin positions restrain actomyosin interactions, whereas in the third position, which is significantly enhanced at high Ca 2+, tropomyosin does …

Nov 6, 2018 · Thin filaments become activated upon Ca2+ binding, which enables strong binding of myosin with a concomitant release of ATP hydrolysis products and level arm swinging …

Apr 29, 2025 · Once calcium ions bind to troponin, tropomyosin repositions, exposing binding sites on actin. Myosin, a motor protein with ATPase activity, binds to these sites, converting …

Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction [2] in skeletal muscle and cardiac …

Troponin binds to tropomyosin and helps to position it on the actin molecule; it also binds calcium ions. To enable a muscle contraction, tropomyosin must change conformation, uncovering the …