After Immunotherapy, Amyloid Clearance Comes Down to …
Mar 14, 2025 · Spatial transcriptomics on human brains parsed microglial reactions to amyloid immunotherapy. Both a vaccine and a therapeutic antibody summoned these cells to plaques. …
Expunging Microglial Lipid Droplets Boosts Phagocytosis
Feb 12, 2025 · Overall, this study elegantly highlights the importance of microglial lipid droplets in amyloid pathology and provides novel insights into their role in microglial function, lipid …
Resting microglial cells are highly dynamic surveillants of brain ...
Apr 27, 2005 · Nimmerjahn et al. have used the two-photon imaging technique to demonstrate the dynamic action of microglial cells in vivo. They were provided with a green fluorescent …
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, …
Oct 30, 2024 · Both in a cultured microglial cell line and in human iPSC-derived microglia, the scientists sparked intracellular aggregates by treating the cells with recombinant ApoE and …
A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter
Jul 11, 2025 · Are T cells blasé about amyloid? Not exactly. Hongbo Chi’s group at St. Jude Children’s Research Hospital in Memphis, Tennessee, showed that in the 5xFAD amyloid …
T cell-mediated microglial activation triggers myelin ... - ALZFORUM
Jun 29, 2024 · News: T Cells in the Brain Goad Microglia to Muddle Myelin This work provides compelling evidence that CD8+ T cells and microglia interactions are pivotal in the myelin …
Microglia-mediated T cell infiltration drives ... - ALZFORUM
Mar 22, 2023 · T-cells, in cross-talk with microglia, promote neurodegeneration, highlighting an interaction between innate and adaptive immunity, well known to occur in the periphery but not …
T Cells in the Brain Goad Microglia to Muddle Myelin
Jun 29, 2024 · In AD, CD8+ T cells infiltrate the brain and release interferon-γ. This stirs highly phagocytic microglia that attack myelin. The microglia cripple oligodendrocytes compromising …
Drivers for Common Microglial States Identified | ALZFORUM
Oct 22, 2025 · As readouts, they selected a marker for each of the most common microglial states: tetraspanin CD9 for DAM, interferon-induced protein IFIT1 for IRM, major …
In Amyloid and Tangle Models, APOE4 Paralyzes Microglia
Oct 26, 2023 · This prevents the cells from clearing amyloid plaques and neurofibrillary tangles. Deleting APOE4, or PU.1, a master driver of microglial homeostasis, enabled the microglia to …