PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. [5] In vertebrates, Pdx1 is necessary for …

PDX1 is a master regulator in pancreas organogenesis, the maturation and identity preservation of β-cells, and of their role in normal insulin function.

Nov 14, 2025 · Complete information for PDX1 gene (Protein Coding), Pancreatic And Duodenal Homeobox 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Also known as insulin promoter factor 1 (IPF1), PDX1 has been studied for its role throughout all phases of pancreatic development. PDX1 is broadly expressed at around 4 weeks with a high …

Nov 30, 2022 · Recent studies have shown that the overexpression of PDX-1 regulates pancreatic development and promotes β-cell differentiation and insulin secretion. It also plays a vital role …

Jan 29, 2021 · Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contribute to islet operation.

PDX1 is a transactivator that binds the TAAT element in the promoter region of target genes, notably those involved in pancreas development (summary by Schwitzgebel et al. (2003)).

Pancreatic ductal and acinar cell tumors and gastric signet ring cell carcinomas are most commonly PDX-1-positive. Most tumors that do not originate from the digestive tract have a …

Dec 15, 2022 · PDX1 is a master regulator in pancreas organogenesis, the maturation and identity preservation of β-cells, and of their role in normal insulin function.

Learn about the PDX1 gene, its critical role in insulin production, and its association with diabetes. Explore its function, regulation, and potential therapeutic applications.